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In renal failure (creatinine clearance less than 30 ml / min), the dose of the drug is reduced by 15-50% and / or the interval between doses is increased to 12 hours. In patients with anuria, the dose of the drug should not Buy Imuran (Azathioprine) exceed 50mg, 25mg online - Pain Relief 2 g per day. For children, the drug is prescribed in doses of 30-60 mg / kg per day, divided into 2-3 doses. With a severe course of an infectious disease, the daily dose for children can be increased to 100 mg / kg. Side effects Nausea, loss of appetite, vomiting, bloating, diarrhea, dry mouth, taste disturbance; hypersensitivity reactions (itching, urticaria); dizziness, convulsions. Contraindications Hypersensitivity to penicillins; cross sensitivity to cephalosporins; Infectious mononucleosis; lymphocytic leukemia; age up to 3 years (tablets, capsules). Nausea, vomiting, diarrhea, violation of water and electrolyte balance. Gastric lavage, the use of enterosorbents (activated carbon), saline laxatives, correction of water and electrolyte balance; if necessary, apply hemodialysis.

Ampicillin Analogues Ampicillin-Health, Ampicillin-Pharmeks, Ampiox-Health, Ampisulbin, Unazine, Ampisid, Ampicillin + Sulbactam-Pharmeks, Timentin, Ampicillin-Darnitsa, Ampicillin trihydrate.

Pharmachologic effect It is active against gram-positive and a number of gram-negative microorganisms.

Indications for use The drug is used to treat patients with pneumonia, lung abscesses, tonsillitis, peritonitis, cholecystitis, sepsis, intestinal infections, postoperative soft tissue infections and other infections caused by susceptible microorganisms.

Dosage and administration Before prescribing a drug to a patient, it is desirable to determine the sensitivity of the microflora to it that caused the disease in this patient. Children are prescribed at the rate of 100 mg / kg. The duration of treatment depends on the severity of the disease and the effectiveness of therapy (from 5-10 days to 2-3 weeks or more).

Side effects Allergic reactions can be observed in the form of skin rash, urticaria, angioedema, etc., in rare cases - anaphylactic shock.

Contraindications The drug is contraindicated in case of hypersensitivity to penicillin.

In hepatic insufficiency, it is used under the control of liver function; with asthma, hay fever and other allergic diseases only if absolutely necessary.

At the same time, desensitizing agents are prescribed.

Toxic effect on the central nervous system; nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea). Gastric lavage, activated charcoal, saline laxatives, maintenance of water and electrolyte balance, symptomatic therapy.

Benzylpenicillin Analogues Penicillin G sodium salt, Retarpen, Bicillin-3, Bicillin-5, Piperacillin-tazobactam-Teva, Aurotaz-R, Zopertsin, Tazar.

Pharmachologic effect It has a bactericidal effect.

Indications for use Infections caused by microorganisms sensitive to the drug: infections of the respiratory tract and upper respiratory tract: tonsillitis, pneumonia, purulent pleurisy, diphtheria, scarlet fever, actinomycosis of the lungs; infections of the genitourinary system: cystitis, syphilis, gonorrhea, colpitis, endocervicitis, endometritis, adnexitis, salpingo-oophoritis; infections of the organ of vision: conjunctivitis, blepharitis, dacryocystitis; purulent infections of the skin and soft tissues; septic endocarditis, sepsis; osteomyelitis; wound infections; erysipelas; anthrax; meningitis; peritonitis; biliary tract infections. Dosage and administration Before administration, it is necessary to conduct an intradermal test for the tolerance of the drug and novocaine, provided that it is used for dilution, in the absence of contraindications to its implementation. The drug is administered intrathecally, intrathecally, into the body cavity.

The most common intramuscular route of administration. V / m: for infections of moderate severity, a single dose of the drug for adults is usually 250,000–500,000 IU, daily - 1–2 million IU, for severe infections, up to 10–20 million IU per day, for gas gangrene - up to 40– 60 million units. Usually the daily dose for children under the age of 1 year is 50,000-100,000 U / kg of body weight, over 1 year - 50,000 U / kg, if necessary, the daily dose can be increased to 200,000-300,000 U / kg, according to vital indicators - up to 500,000 U / kg.