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The duration of treatment depends on the severity of the disease and the effectiveness of therapy (from 5-10 days to 2-3 weeks or more).

Side effects Allergic reactions can be observed in the form of skin rash, urticaria, angioedema, etc., in rare cases - anaphylactic shock. Contraindications The drug is contraindicated in case of hypersensitivity to penicillin.

In hepatic insufficiency, it is used under the control of liver function; with asthma, hay fever and other allergic diseases only if absolutely necessary.

At the same time, desensitizing agents are prescribed.

Toxic effect on the central nervous system; nausea, vomiting, diarrhea, disturbance of water and electrolyte balance (as a result of vomiting and diarrhea). Gastric lavage, activated charcoal, saline laxatives, maintenance of water and electrolyte balance, symptomatic therapy. Benzylpenicillin Analogues Penicillin G sodium salt, Retarpen, Bicillin-3, Bicillin-5, Piperacillin-tazobactam-Teva, Aurotaz-R, Zopertsin, Tazar.

Pharmachologic effect It has a bactericidal effect.

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the tolerance of the drug and novocaine, provided that it is used for dilution, in the absence of contraindications to its implementation. The drug is administered intrathecally, intrathecally, into the body cavity.

The most common intramuscular route of administration. V / m: for infections of moderate severity, a single dose of the drug for adults is usually 250,000500,000 IU, daily - 12 million IU, for severe infections, up to 1020 million IU per day, for gas gangrene - up to 40 60 million units.

Usually the daily dose for children under the age of 1 year is 50,000-100,000 U / kg of body weight, over 1 year - 50,000 U / kg, if necessary, the daily dose can be increased to 200,000-300,000 U / kg, according to vital indicators - up to 500,000 U / kg. The frequency of administration of the drug - 4-6 times a day.

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